芒果直播

New research supported by 芒果直播 has confirmed that a person鈥檚 genes can influence how well widely used diabetes medicines such as Mounjaro and Ozempic work.

The discovery could pave the way for more personalised prescribing in the future, with treatments tailored to a person鈥檚 genetic profile to improve outcomes.

The findings come from an international team including researchers at Adelaide University and were published in the international journal .

The research was led by South Australian endocrinologist and clinician researcher Dr Mahesh Umapathysivam (Adelaide University), Dr Alraldi (ETH Zurich), Professor Gloyn (Stanford University) and Prof Stoffel (ETH Zurich), and was supported in Adelaide by funding from the 芒果直播 Research Program in 2024.

Dr Umapathysivam said the team investigated how genetic differences affect responses to medicines known as GLP-1 receptor agonists, a class of drugs that help lower blood glucose levels and can also assist with weight loss.

鈥淥ur studies suggest that a person鈥檚 genetic profile may influence how well these medicines slow the emptying of the stomach after eating,鈥� Dr Umapathysivam said.

鈥淭his process is important because slower stomach emptying contributes to the medicines鈥� effect on blood glucose levels.鈥�

The research studied the effect of genetic variants which alter the activity of a protein called PAM. Approximately 10% of the population carry a loss-of-function variant in the PAM gene and have lower PAM activity and higher levels of GLP-1 after meals, but without the expected improvement in the body鈥檚 ability to lower blood glucose after a meal, something known as the 鈥渋ncretin鈥� response.

鈥淎s a result, these individuals showed a reduced response to GLP-1 receptor agonist medicines,鈥� Dr Umapathysivam said.

鈥淥ur findings suggest that people who carry these variants may have a form of GLP-1 resistance, meaning the medicines may not work as effectively for them.鈥�

The team also observed similar patterns in mouse studies, strengthening the evidence that genetic differences can influence how patients respond to this class of medicines.

The discovery could help guide future precision medicine approaches, allowing doctors to better predict who is likely to benefit from these treatments and who may need alternative therapies.

Adelaide鈥檚 Laverne Naicker, who was diagnosed with type 2 diabetes about 20 years ago, said she thought it was a shame when Ozempic didn鈥檛 work for her.

鈥淚 was pretty disappointed,鈥� Laverne said. 鈥淚t was a big deal. Ozempic seemed to work like a miracle for other people, so why not me?

鈥淔or every medication there are side effects. For me, I experienced burping, abdominal discomfort like pinching, and terrible headaches.

鈥淭here was no flip side. Ozempic didn鈥檛 help with my diabetes. This research is awesome because it has the potential for people like me not to waste time, hope, and feeling unwell if the medication isn鈥檛 going to work.鈥�

Laverne has since started insulin to help manage her glucose levels.

芒果直播鈥檚 Group CEO Justine Cain said the results highlighted the importance of sustained investment in diabetes research.

鈥溍⒐�直播 is proud to have supported this groundbreaking project,鈥� Ms Cain said.

鈥淩esearch is the key to changing the future of diabetes.

鈥淚nnovative studies like this show how Australian researchers are helping lead the world in understanding diabetes, how to prevent it, and how to improve treatment for people living with the condition.鈥�

芒果直播 Group Executive, Health, Economics & Research, Amber Willink, said Dr Umapathysivam鈥檚 team鈥檚 research supports treatments being used where they will have the greatest benefit.

“Personalised medicine is not a future concept. It鈥檚 emerging now. This research shows how genetic insights can help ensure the right treatment reaches the right person at the right time.”

Researchers from the University of Oxford, University of Dundee, University of Copenhagen, University of British Columbia, Newcastle University, University of Bath and University of Exeter also contributed to the work. 

Established almost 40 years ago, the 芒果直播 Research Program supports outstanding research across prevention, treatment and the search for a cure for all types of diabetes.

The program also helps develop the next generation of diabetes researchers and relies on the generosity of donors to continue supporting world-class research in Australia.

More information about the 芒果直播 Research Program and how to support its work is available at the 芒果直播 website. Find out more about how to support us.